The body's molecular mail.
EVs are microscopic particles cells secrete to communicate. Each one carries a cargo of proteins, lipids, and nucleic acids — a snapshot of the cell that sent it, and of the tissue it lives in.
Interstitial-fluid EV isolation
Capture vesicles where the biology actually happens.
ExoBiosciences kits draw extracellular vesicles straight from the interstitial fluid of living tissue — recovering the cell-to-cell signals that cell culture never sees, with the tissue left intact for everything downstream.
From sample to signal
The basics
The space between cells is full of messages.
Cells constantly package proteins, lipids, and genetic material into vesicles and release them to talk to one another. ExoBiosciences reads that conversation where it actually happens — in the fluid around the cells.
The wet matrix around every cell.
Interstitial fluid fills the spaces between cells in living tissue — the matrix that bathes every tumor cell. It's where vesicles are released, exchanged, and routed into lymphatic drainage, and where we collect them.
Why interstitial fluid
The tissue microenvironment is a different signal than the culture dish.
Vesicles in the interstitial fluid carry the live molecular state of the tissue around them — a class of information you can't recover once cells are pulled into culture.
Captured at the source
EVs are harvested directly from the tissue microenvironment in vivo — not regenerated by cells adapting to a flask — so their cargo reflects real biology.
Information you can't culture
Tumor interstitial-fluid EVs surface molecular content absent from cultured-cell EVs — opening biomarkers that standard lab models simply miss.
Tissue stays intact
Gentle, spin-free collection preserves histology, so the same biopsy still feeds your pathology and downstream molecular assays after isolation.
The kit
One step, one tube, living tissue in.
The collection tube isolates EVs of every subtype from an excised tissue biopsy. It shields the sample from damaging centrifugal force and uses a separation matrix to draw vesicles out of the interstitial space — reproducible enrichment, no specialized rig.
- All EV subtypes — from large EVs through exosomes, in a single pass.
- No damaging spin — the matrix does the work, protecting cell viability and morphology.
- Reproducible — consistent enrichment you can build a study around.
- Downstream-ready — compatible with proteomics, transcriptomics, and histology.
From sample to signal
A clean line from excised tissue to interpretable biology.
01
Collect
Place excised tissue in the collection tube. Interstitial fluid releases without disrupting cell viability or morphology.
02
Isolate
The separation matrix enriches EVs across all subtypes with high, study-grade reproducibility.
03
Profile
Run proteomic, transcriptomic, and surface-marker panels on cargo that reflects the true tissue state.
04
Interpret
Our analysis layer turns vesicle multi-omics into ranked, comparable signals across samples.
On the roadmap
Validation
Verified at the source.
In syngeneic tumor models, interstitial-fluid EVs carried tumor-cell–specific markers — confirming their in vivo origin — while the surrounding tissue stayed structurally intact through isolation.
Confirmed EV identity
Canonical surface and tetraspanin markers confirm bona-fide vesicles across enriched subpopulations.
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Beyond the culture dish
Mass-spectrometry profiles reveal molecular content unique to interstitial-fluid EVs versus matched cultured-cell EVs.
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Histology preserved
Pre- and post-isolation sections are comparable — the tissue remains compatible with the full panel of downstream assays.
pathology-ready
Applications
Built for the questions culture models can't answer.
01
Early cancer detection
Profile interstitial-fluid EV cargo for biomarkers that surface disease early — at the molecular state of the living tumor, before it shows elsewhere.
02
Metastatic signaling
Tumors release IF EVs that prime distant sites like lymph nodes for spread. Capture that cross-talk at its source to study how metastasis is set up.
03
Mitochondrial health & response
Read vesicle signals such as the PINK1 fragmentation ratio to gauge oxidative stress and track how tissue responds to therapy.
Bring interstitial-fluid EVs into your lab.
Tell us about your tissue and your endpoints, and we'll scope the right kit configuration for your study.